Establishing the origin of the lapis lazuli used in ancient artefacts has long been beyond the reach of science. Now an innovative technique has revealed, in a non-invasive way, where the precious stone was coming from. Alessandro Lo Giudice, Alessandro Re, Laura Guidorzi, Marta Magalini, Norman Hammond, Randall Law, Guy Clutterbuck, and Georgina Herrmann guide us from a laboratory in Italy to a remote mine.